franklin disease การใช้

• The fever is considered secondary to impaired cellular and humoral immunity, and thus recurrent infections are the common clinical presentation in Franklin disease.
• Patients with Franklin disease usually have a history of progressive weakness, fatigue, intermittent fever, night sweats and weight loss and may present with lymphadenopathy ( 62 % ), splenomegaly ( 52 % ) or hepatomegaly ( 37 % ).
• Weng et al . described the first case of Penicillium sp . infection in a patient with Franklin disease and emphasized the importance of proper preparation for biopsy, complete hematologic investigation, culture preparation and early antifungal coverage to improve the outcome.